کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5212172 | 1383107 | 2017 | 4 صفحه PDF | دانلود رایگان |
Enzyme triggered bio-catalytic reactions convert chemical energy into mechanical force to power micro/nano-machines. Though there have been reports about enzymes powered micro/nano-motors, enzymatic Janus nano-motor smaller than 100Â nm has not been reported yet. Here, we prepared an enzyme powered Janus nano-motor by half-capping a thin layer of silicon dioxide (4Â nm SiO2) onto a mesoporous silica nanoparticle (MSNP) of 90Â nm, enabling asymmetry to the nano-architecture. The nano-motors are chemically powered by the decomposition of H2O2 triggered by the enzyme catalase located at one face of the nanoparticles. The self-propulsion is characterized by dynamic light scattering (DLS) and optical microscopy. The apparent diffusion coefficient was enhanced by 150% compared to their Brownian motion at low H2O2 concentration (i.e. below 3Â wt%). Mesoporous nano-motors might serve as active drug delivery nano-systems in future biomedical applications such as intracellular drug delivery.
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Journal: Tetrahedron - Volume 73, Issue 33, 17 August 2017, Pages 4883-4886