کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5213104 | 1383145 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total synthesis, biological evaluation of dendrodolides A-D and their analogues
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Total synthesis, biological evaluation of dendrodolides A-D and their analogues Total synthesis, biological evaluation of dendrodolides A-D and their analogues](/preview/png/5213104.png)
چکیده انگلیسی
A concise total synthesis of dendrodolides A-D (1-4) has been accomplished in 10 steps from commercially available (R)-propylene oxide and 3-buten-1-ol as starting materials. The key steps involved in the synthesis are Jacobsen hydrolytic kinetic resolution, epoxide ring opening with 2-allyl-1, 3-dithiane, Yamaguchi esterification and ring-closing metathesis (RCM). In addition, a series of ester derivatives were prepared utilizing Yamaguchi esterification at the C-3 position of the dendrodolide core and screened for their efficacy against cancer cell lines.
145
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 72, Issue 32, 11 August 2016, Pages 4789-4797
Journal: Tetrahedron - Volume 72, Issue 32, 11 August 2016, Pages 4789-4797
نویسندگان
B. Poornima, A. Venkanna, B. Swetha, Karthik reddy Kamireddy, Bandi Siva, V.S. Phani Babu, Ramesh Ummanni, K. Suresh Babu,