کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5213134 | 1383146 | 2016 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Campyridones A-D, pyridone alkaloids from a mangrove endophytic fungus Campylocarpon sp. HDN13-307 Campyridones A-D, pyridone alkaloids from a mangrove endophytic fungus Campylocarpon sp. HDN13-307](/preview/png/5213134.png)
Two pairs of epimers, campyridones A and B (1 and 2) and campyridones C and D (3 and 4), were isolated from the mangrove endophytic fungus Campylocarpon sp. HDN13-307, as well as the biogenetically related known ilicicolin H (5). Their structures including absolute configurations were elucidated on the basis of the spectroscopic analysis and ECD calculations. The new compounds 1-4 possess unprecedented ring systems featured by the appearance of an additional spiro-furanone (1/2) or γ-pyrone (3/4) moieties (C ring), which represents a new family of 4-hydroxy-2-pyridone alkaloids. Compounds 4 and 5 were cytotoxic against Hela cell with IC50 values of 8.8 μM and 4.7 μM, respectively. A plausible biosynthetic pathway for 1-4 is also elucidated.
Journal: Tetrahedron - Volume 72, Issue 37, 15 September 2016, Pages 5679-5683