Sesquiterpene isocyanides, isothiocyanates, thiocyanates, and formamides from the Thai sponge Halichondria sp.

Nine new nitrogenous sesquiterpenes (1-9) were isolated together with 11 known compounds (10-20) from the Thai marine sponge Halichondria sp. The structures of the isolated compounds were determined on the basis of extensive NMR studies and high-resolution MS measurements as well as comparison with literature data. Sixteen of these metabolites were evaluated for cytotoxic activity against six tumor cell lines.

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