کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5213641 | 1383165 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oligo-polyethene glycol (PEG)-modified 14-deoxy-11,12-didehydroandrographolide derivatives: synthesis, solubility and anti-bacterial activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A class of 14-deoxy-11,12-didehydroandrographolide (DA) derivatives with oligo-polyethylene glycol (PEG) substituents has been synthesized. It is found that small degree of polymerization of PEG favors the synthesis of dual-PEGylated DA derivatives, whereas large degree of polymerization is good for the preparation of mono-PEGylated DA derivatives. As compared to the prototype compound DA, the PEGylated DA derivatives show enhanced water solubility which is beneficial to drug's bioavailability. Preliminary study finds that the PEGylated DA derivatives exhibit better anti-bacterial activity than that of DA.
100
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 72, Issue 18, 5 May 2016, Pages 2265-2270
Journal: Tetrahedron - Volume 72, Issue 18, 5 May 2016, Pages 2265-2270
نویسندگان
Zhen Wang, Yi Chen, Feipeng Wu,