کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5213641 1383165 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oligo-polyethene glycol (PEG)-modified 14-deoxy-11,12-didehydroandrographolide derivatives: synthesis, solubility and anti-bacterial activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Oligo-polyethene glycol (PEG)-modified 14-deoxy-11,12-didehydroandrographolide derivatives: synthesis, solubility and anti-bacterial activity
چکیده انگلیسی

A class of 14-deoxy-11,12-didehydroandrographolide (DA) derivatives with oligo-polyethylene glycol (PEG) substituents has been synthesized. It is found that small degree of polymerization of PEG favors the synthesis of dual-PEGylated DA derivatives, whereas large degree of polymerization is good for the preparation of mono-PEGylated DA derivatives. As compared to the prototype compound DA, the PEGylated DA derivatives show enhanced water solubility which is beneficial to drug's bioavailability. Preliminary study finds that the PEGylated DA derivatives exhibit better anti-bacterial activity than that of DA.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 72, Issue 18, 5 May 2016, Pages 2265-2270
نویسندگان
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