Asymmetric synthesis of the constitutive C22-carboxylic acid of macroviracin A

An enantioconvergent synthesis of the advanced intermediate of macroviracin A has been developed, using enantioselective lipase-catalyzed acylation, asymmetric allylation, and asymmetric dihydroxylation reaction to install the required stereogenic centers. The key reactions proceeded with good to excellent stereoselectivity.