کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215611 | 1383237 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regioselective synthesis of 5â²-amino acid esters of some nucleosides via orthogonal protecting protocol
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regioselective synthesis of 5â²-amino acid esters of some nucleosides via orthogonal protecting protocol Regioselective synthesis of 5â²-amino acid esters of some nucleosides via orthogonal protecting protocol](/preview/png/5215611.png)
چکیده انگلیسی
Amino acid esters of nucleosides at 5â²-position, as peptidomimetic prodrugs, which could be actively transported by the intestinal oligopeptide transporters 1 (PepT1), bear improved oral bioavailability. We established here a regioselective synthesis of the 5â²-esters of some nucleosides via an orthogonal protecting protocol with triphenylmethyl (Tr) and allyloxycarbonyl (AOC) protecting groups. A series of 5â²-esters of cytarabine and gemcitabine were selectively synthesized in over 36.0% total yields. This efficient and robust methodology will be examplified for the further study of the prodrugs of large number of antiviral and anticancer nucleosides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 9, 4 March 2015, Pages 1409-1412
Journal: Tetrahedron - Volume 71, Issue 9, 4 March 2015, Pages 1409-1412
نویسندگان
Jia-An Liu, Xiao-Peng Guo, Shuang Liang, Fei An, Hong-Yan Shen, You-Jun Xu,