کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5216266 1383257 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of triazolyl-linked polysialic acids
ترجمه فارسی عنوان
سنتز اسیدهای پلیسیالیک مرتبط با تیاسولیل
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A new approach for the synthesis of triazolyl-linked α-(2-9) oligosialic acids by iterative copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) and desilylation has been developed. By using propargyl α-sialoside 5 and trimethylsilylated-propargyl 9-azido-α-sialoside 3 as building blocks, triazolyl-linked α-(2-9) di- to octa-sialic acids were constructed in good to moderate yields. Finally, the pseudo-α-(2-9)-oligosialic acids were obtained very smoothly via O-deprotection. The oligosialic acids with a triazolyl-linkage represent a new type of pseudooligosialic acids. This protocol may find applications in the preparation of oligosialic acid analogues with biological importance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 70, Issue 49, 9 December 2014, Pages 9405-9412
نویسندگان
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