کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5216584 | 1383269 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ivorenoids A-F: limonoids from Khaya ivorensis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Six new limonoids, ivorenoids A-F (1-6), along with ten known analogues, were isolated from an ethanolic extract of the stems of Khaya ivorensis. Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 and 2 possessed a rare rearranged skeleton of khayanolides and a unique γ-lactone (C-16/C-8) replacing the common and characteristic δ-lactone D-ring (C-16/C-17) of limonoids. A mechanism of the interesting deuteration of H-2 and H-15β of 1, and H-15β of the solvent CD3OD due to the keto-enol tautomerism was demonstrated. Compounds 3 and 6 showed moderate activity against HL-60 cell line with IC50 values of 15.3 and 17.5 μM, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 70, Issue 22, 3 June 2014, Pages 3570-3575
Journal: Tetrahedron - Volume 70, Issue 22, 3 June 2014, Pages 3570-3575
نویسندگان
Wen-Bin Wu, Hua Zhang, Hong-Chun Liu, Shi-Hui Dong, Yan Wu, Jian Ding, Jian-Min Yue,