کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5216909 | 1383280 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intervenolin is a natural antitumor quinolone that inhibits the growth of MKN-74 gastric tumor cells cocultured with Hs738 gastric stromal cells, and exhibits selective anti-Helicobacter pylori activities. In this report, a structure-activity relationship study of intervenolin is presented. Suitable substituents on the nitrogen, including iminodithiocarbonate moiety, alleviated acute toxicity, and four derivatives displayed specific anti-H. pylori activity. One intervenolin analog with quinoline scaffold also exhibited selective growth inhibition toward cocultured MKN-74, and in vivo antitumor effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 36, 9 September 2013, Pages 7608-7617
Journal: Tetrahedron - Volume 69, Issue 36, 9 September 2013, Pages 7608-7617
نویسندگان
Hikaru Abe, Manabu Kawada, Hiroyuki Inoue, Shun-ichi Ohba, Tohru Masuda, Chigusa Hayashi, Masayuki Igarashi, Akio Nomoto, Takumi Watanabe, Masakatsu Shibasaki,