کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5217661 | 1383302 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A general synthesis of tetrahydropyrazolo[3,4-d]thiazoles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A general synthesis of tetrahydropyrazolo[3,4-d]thiazoles A general synthesis of tetrahydropyrazolo[3,4-d]thiazoles](/preview/png/5217661.png)
چکیده انگلیسی
A short three-step synthesis of tetrasubstituted 3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles has been worked out. This relatively unknown heterobicyclic system is assembled from two carbonyl compounds, an amine, a hydrazine, and mercaptoacetic acid ester. These versatile starting materials allow the introduction of a broad range of alkyl, haloalkyl, cycloalkyl, aryl, and heteroaryl substituents into four different positions of the bicyclic scaffold. The efficiency of the synthesis route is proven by the fact, that two of the three steps are a multicomponent reaction or a cascade reaction, respectively, and that it can further be shortened to two consecutive one-pot processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 23, 10 June 2013, Pages 4641-4651
Journal: Tetrahedron - Volume 69, Issue 23, 10 June 2013, Pages 4641-4651
نویسندگان
Sophie Pelletier, Benjamin Pinson, Tomas Smejkal, Clemens Lamberth,