Asymmetric syntheses of dihydroxyhomoprolines via doubly diastereoselective lithium amide conjugate addition reactions

122The asymmetric syntheses of dihydroxyhomoprolines were achieved using the doubly diastereoselective conjugate addition of enantiopure lithium amides to d-pentose derived α,β-unsaturated esters followed by an intramolecular reductive amination as the key steps.