کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5218218 1383320 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simple, efficient one-pot method for synthesis of novel N-attached 1,2,3-triazole containing bisphosphonates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Simple, efficient one-pot method for synthesis of novel N-attached 1,2,3-triazole containing bisphosphonates
چکیده انگلیسی

A practical and efficient one-pot method for synthesis of a novel kind of N-attached 1,2,3-triazole-containing bisphosphonates was developed. Michael addition reaction of sodium azide with ethylidene bisphosphonates and 1,3-dipolar click cycloaddition were reasonably integrated into one-pot reaction in the presence of sonication. Vinylidene bisphosphonate, NaN3, and terminal alkyne were employed as the reactants, CuSO4·5H2O sodium ascorbate was employed as the catalyst system, and AcOH/H2O (1:1 v/v) were employed as the solvent system to create an acidic environment to achieve optimal efficiency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 20, 20 May 2013, Pages 4047-4052
نویسندگان
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