کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5218368 1383325 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient synthesis of l-3,4,5-trioxygenated phenylalanine compounds from l-tyrosine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient synthesis of l-3,4,5-trioxygenated phenylalanine compounds from l-tyrosine
چکیده انگلیسی

A new strategy for the synthesis of l-3,4,5-trioxygenated phenylalanine derivatives from l-tyrosine is developed for the first time. The approach, featuring the transformation of aryl diiodide to bis-phenol via a one-pot procedure including lithiation, boronation, and oxidation, is highly practical. By this robust protocol, N-protected l-3,5-bis(tert-butyldimethylsilyloxy)-4-methoxy-phenylalanine and l-3,4,5-trimethoxy-phenylalanine derivatives were obtained from l-tyrosine in 9 steps with 36-40% overall yields.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 17, 29 April 2013, Pages 3565-3570
نویسندگان
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