کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5220292 1383383 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of spongidines A and D: marine metabolites phospholipase A2 inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of spongidines A and D: marine metabolites phospholipase A2 inhibitors
چکیده انگلیسی

Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate.

Spongidines A and D have been synthesized. Two routes have been optimized and the key compound is chloroderivative 13.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 20, 20 May 2011, Pages 3649-3658
نویسندگان
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