کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220381 | 1383386 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aromatic garlands, as new foldamers, to mimic protein secondary structure
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Proteins modulate the majority of all biological functions and are composed of highly organized secondary structural elements such as helices, turns, and sheets. Many of these functions are affected by a small number of key structural element, protein-protein interactions. Their mimicry by peptide and non-peptide scaffolds has become a major focus of contemporary research. This paper examines oligomeric system as new foldamers, which either reproduce the local topography of the helix, or project appropriately functionality in a similar manner to residues of an alpha-helix.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 23, 10 June 2012, Pages 4381-4389
Journal: Tetrahedron - Volume 68, Issue 23, 10 June 2012, Pages 4381-4389
نویسندگان
Anne Sophie Voisin-Chiret, Grégory Burzicki, Serge Perato, Marcella De Giorgi, Carlo Franchini, Jana Sopková-de Oliveira Santos, Sylvain Rault,