کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5220381 1383386 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aromatic garlands, as new foldamers, to mimic protein secondary structure
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Aromatic garlands, as new foldamers, to mimic protein secondary structure
چکیده انگلیسی

Proteins modulate the majority of all biological functions and are composed of highly organized secondary structural elements such as helices, turns, and sheets. Many of these functions are affected by a small number of key structural element, protein-protein interactions. Their mimicry by peptide and non-peptide scaffolds has become a major focus of contemporary research. This paper examines oligomeric system as new foldamers, which either reproduce the local topography of the helix, or project appropriately functionality in a similar manner to residues of an alpha-helix.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 23, 10 June 2012, Pages 4381-4389
نویسندگان
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