کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5220577 1383392 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography
چکیده انگلیسی

Efficient self-disproportionation of enantiomers of several non-racemic chiral amines was achieved through conversion to N-acetamides and subsequent MPLC using an achiral column. The MPLC of these non-racemic N-acetamide derivatives gave the chart having a clear boundary between two fractions. Thus, in the less polar fraction, remarkable enantiomer enrichment was observed (>99%ee), while the ee of more polar fraction was considerably reduced. The magnitude of the enantiomer enrichments and depletions strongly depended on substituent on the amino group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 21, 27 May 2012, Pages 4013-4017
نویسندگان
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