کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5220855 | 1383401 | 2011 | 5 صفحه PDF | دانلود رایگان |
Five nitrogenous sesquiterpenes having an isonitrile [(â)-axisonitrile-3], a formamide [(+)-axamide-3, axamide-2 and (3S*,5R*,6R*,9R*)-3-formamido-1(10)-cadinene], and an amine [(â)-halichamine] functionality were isolated from the Thai marine sponge Halichondria sp., together with two steroids, ergosterol and ergosterol peroxide. (â)-Axisonitrile-3 was isolated from the natural source for the first time, while (+)-axamide-3 and (â)-halichamine were new metabolites. The structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformations. All sesquiterpenes were tested for their cytotoxic activity against six cancer cell lines (HeLa, HuCCA-1, A549, MOLT-3, HepG2, MDA-MB231). Only (â)-axisonitrile-3 showed strong activity to the HepG2 cell line with an IC50 value of 1.3 μM.
Journal: Tetrahedron - Volume 67, Issue 31, 5 August 2011, Pages 5651-5655