کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221027 | 1383407 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of the repeating unit of the lipoteichoic acid of Streptococcus pneumoniae
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of the repeating unit of the lipoteichoic acid of Streptococcus pneumoniae Synthesis of the repeating unit of the lipoteichoic acid of Streptococcus pneumoniae](/preview/png/5221027.png)
چکیده انگلیسی
The lipoteichoic acid repeating unit of Streptococcus pneumoniae is a complex pseudopentasaccharide (3). It consists of one ribitol-phosphate, one 2-acetamino-4-amino-2,4,6-trideoxy-galactose, one glucose and two galactosamine residues each differently linked, but both carrying one phosphocholine substituent, at position 6. Suitable building blocks (6-10) for efficient and diastereocontrolled ligations were designed, thus providing, after complete deprotection, the target molecule in high purity. Biological tests revealed that repeating unit 3, lacking the lipid moiety, did not stimulate a pro-inflammatory response in human monocytes (hMNCs).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 4, 28 January 2012, Pages 1052-1061
Journal: Tetrahedron - Volume 68, Issue 4, 28 January 2012, Pages 1052-1061
نویسندگان
Christian Marcus Pedersen, Ignacio Figueroa-Perez, Artur J. Ulmer, Ulrich Zähringer, Richard R. Schmidt,