کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221048 | 1383407 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of new imidazol-2-yl-(amino)methylphosphonates, phosphinates and phosphine oxides and their unexpected cleavage under acidic conditions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation of new imidazol-2-yl-(amino)methylphosphonates, phosphinates and phosphine oxides and their unexpected cleavage under acidic conditions Preparation of new imidazol-2-yl-(amino)methylphosphonates, phosphinates and phosphine oxides and their unexpected cleavage under acidic conditions](/preview/png/5221048.png)
چکیده انگلیسی
The efficient synthesis of new imidazol-2-yl-(amino)methylphosphonic acids, phosphonates phosphinate esters and phosphine oxides is described. The synthetic methodology is based on nucleophilic addition of phosphorus species to imidazole-2 derived imines. Additionally, it was discovered that heating the imidazol-2-yl-(amino)methylphosphonates with aqueous HCl or H2SO4 leads to their decomposition resulting in a rupture of the C-P bond, elimination of the phosphorous-containing fragment and formation of the corresponding secondary imidazole-2 alkylamines. A mechanistic pathway for the cleavage is postulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 4, 28 January 2012, Pages 1223-1229
Journal: Tetrahedron - Volume 68, Issue 4, 28 January 2012, Pages 1223-1229
نویسندگان
Bogdan Boduszek, Tomasz K. Olszewski, Waldemar Goldeman, Kamila Grzegolec, Patrycja Blazejewska,