کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221162 | 1383412 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A one-pot three-component reaction for the preparation of highly functionalized tryptamines A one-pot three-component reaction for the preparation of highly functionalized tryptamines](/preview/png/5221162.png)
We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described.
We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described.
Journal: Tetrahedron - Volume 68, Issue 3, 21 January 2012, Pages 813-818