Synthesis of (+)-makassaric acid, a protein kinase MK2 inhibitor

Description of the first synthesis of (+)-makassaric acid, an important kinase MK2 inhibitor. The key step was a Barton/McCombie radical deoxygenation.

(+)-Makassaric acid has been synthesized from (−)-sclareol, through a Barton/McCombie reaction.