Keywords: مهار کننده های پروتئین کیناز; Adverse events; Hypertension; Lenvatinib; Patient Safety; Protein kinase inhibitors; Proteinuria; Thyroid neoplasms;
مقالات ISI مهار کننده های پروتئین کیناز (ترجمه نشده)
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Keywords: مهار کننده های پروتئین کیناز; Semicircular canal; Hair cells; Potassium currents; Sensory discharge; Forskolin; Protein kinase inhibitors;
Keywords: مهار کننده های پروتئین کیناز; Angiogenesis inhibitors; Neovascularization; Pharmacokinetics; Pharmacodynamics; Protein kinase inhibitors; Monoclonal antibodies;
Keywords: مهار کننده های پروتئین کیناز; Drug discovery; Molecular docking; Protein kinase inhibitors;
Keywords: مهار کننده های پروتئین کیناز; Protein kinase inhibitors; Capillary electrophoresis; Electrophoretically mediated microanalysis; LC-MS/MS; Natural extracts;
Keywords: مهار کننده های پروتئین کیناز; Targeted therapies; Therapeutic drug monitoring; Pharmacokinetics; Variability; Tyrosine kinase inhibitors; Protein kinase inhibitors; Monoclonal antibodies; Target concentration
Keywords: مهار کننده های پروتئین کیناز; miRNA; micro RNA; PRISM; PRotein Interactions by Structural Matching; RNAi; RNA interference; Anti-cancer therapies; Autophagy; Cancer attractors; Cancer stem cells; Game theory; Inflammation; Interactome; Metabolic modeling; Networks; Protein kinase inhi
Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents
Keywords: مهار کننده های پروتئین کیناز; Protein kinase inhibitors; Tetrahalobenzimidazoles; Anticancer effects; Flow cytometry;
Targeting MET in cancer therapy
Keywords: مهار کننده های پروتئین کیناز; Proto-oncogene protein c-MET; Antineoplastic agents; Protein kinase inhibitors; Molecular targeted therapy;
Secretagogues of lung surfactant increase annexin A7 localization with ABCA3 in alveolar type II cells
Keywords: مهار کننده های پروتئین کیناز; Lung surfactant secretion; Exocytosis; Membrane fusion; Lamellar bodies; Protein kinase inhibitors; A7 phosphorylation;
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents
Keywords: مهار کننده های پروتئین کیناز; LRRK2 inhibitors; Protein kinase inhibitors; Indolinone; Adult neurogenesis; Neural stem cell; Regenerative medicine;
Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity ★
Keywords: مهار کننده های پروتئین کیناز; Urothelial carcinoma; Bladder; Neoadjuvant therapy; Protein kinase inhibitors; Src-family kinases; Dasatinib; Translational medical research
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties
Keywords: مهار کننده های پروتئین کیناز; Anthra[2,3-b]furan-3-carboxamides; DNA ligands; Topoisomerase inhibitors; Protein kinase inhibitors; Cytotoxicity; Circumvention of multidrug resistance; Antitumor activity; CDI; 1,1â²-carbonyldiimidazole; DCC; N,Nâ²-dicyclohexylcarbodiimide; EDC; 1-eth
Selected 4-phenyl hydroxycoumarins: In vitro cytotoxicity, teratogenic effect on zebrafish (Danio rerio) embryos and molecular docking study
Keywords: مهار کننده های پروتئین کیناز; 4-Phenyl hydroxycoumarins; Cytotoxicity; Molecular docking; Teratogenic potential; Protein kinase inhibitors;
Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma
Keywords: مهار کننده های پروتئین کیناز; Melanoma; Protein kinase inhibitors; Molecular targeted therapy; Proto-oncogene proteins B-raf; Dabrafenib; Trametinib;
Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads
Keywords: مهار کننده های پروتئین کیناز; Mps1; TTK; Protein kinase inhibitors; Scaffold hopping; Conformational restriction; Structure-based design; Cancer; Purines; Pyrrolopyrimidines; Quinazoline;
Effective synthesis of 3,5-diaryl-(1H)-pyrazin-2-ones via microwave mediated ring closure
Keywords: مهار کننده های پروتئین کیناز; 3,5-Diaryl-(1H)-pyrazin-2-ones; Microwave reaction; Aryl-α-ketoamines; Aryl-glyoxylic acids; Protein kinase inhibitors;
Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2
Keywords: مهار کننده های پروتئین کیناز; CK2; Protein kinase inhibitors; TBB; Chemoproteomics; Inhibitor profiling; Mass spectrometry;
Preclinical Rationale for PI3K/Akt/mTOR Pathway Inhibitors as Therapy for Epidermal Growth Factor Receptor Inhibitor-Resistant Non–Small-Cell Lung Cancer
Keywords: مهار کننده های پروتئین کیناز; 1-phosphatidylinositol 3-kinase/antagonists and inhibitors; Carcinoma; Drug resistance; Epidermal growth factor antagonists and inhibitors; Neoplasm/physiology; Non–small-cell lung cancer drug therapy; Protein kinase inhibitors; Receptor
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
Keywords: مهار کننده های پروتئین کیناز; NCLLROQWWLCOFF-UHFFFAOYSA-N; p38α; Protein kinase inhibitors; X-ray crystal structure;
Recent results in protein kinase inhibition for tropical diseases
Keywords: مهار کننده های پروتئین کیناز; Protein kinase inhibitors; Parasitic diseases;
Thyroid Dysfunction in Patients Treated With Sunitinib or Sorafenib
Keywords: مهار کننده های پروتئین کیناز; Biologic markers; Enzyme inhibitors; Hypothyroidism; Kidney neoplasms; Protein kinase inhibitors; Sorafenib; Sunitinib
Quantifying insulin receptor isoform expression in FFPE breast tumors
Keywords: مهار کننده های پروتئین کیناز; Real-time; qPCR; Breast cancer; Receptor insulin; Receptor IGF Type 1; Monoclonal antibodies therapeutic use; Protein kinase inhibitors
Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure
Keywords: مهار کننده های پروتئین کیناز; Anticancer; Hydrazides; Indoles; Protein kinase inhibitors; Suzuki reaction
Synthesis of (+)-makassaric acid, a protein kinase MK2 inhibitor
Keywords: مهار کننده های پروتئین کیناز; Makassaric acid; Subersic acid; Meroterpenoids; Protein kinase inhibitors; Barton/McCombie;
Rôle de la voie de l'IGF dans les cancers bronchiques
Keywords: مهار کننده های پروتئین کیناز; Cancer du poumon; Inhibiteurs de la protéine kinase; IGF-1R; Les marques de tumeurs; Lung cancer; Protein kinase inhibitors; IGF-1R; Tumour markers;
Addiction to protein kinase CK2: A common denominator of diverse cancer cells?
Keywords: مهار کننده های پروتئین کیناز; ALCL; anaplastic large cell lymphoma; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CML; chronic myeloid leukemia; MDR; multi-drug resistance; MM; multiple myeloma; NF-kB; nuclear factor-kB; PDK1; 3â²-phosphoinositide-dependent kinase-1
Synthesis and cytotoxicity of novel indirubin-5-carboxamides
Keywords: مهار کننده های پروتئین کیناز; Indirubin; Chemical synthesis; Antitumor agents; Protein kinase inhibitors
Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa
Keywords: مهار کننده های پروتئین کیناز; Laguncularia racemosa; Combretaceae; White mangrove; Phenolic compounds; Structure elucidation; Anti-oxidative activity; Protein kinase inhibitors; Insecticidal activity;
Optimising chronic myeloid leukaemia therapy in the face of resistance to tyrosine kinase inhibitors – A synthesis of clinical and laboratory data
Keywords: مهار کننده های پروتئین کیناز; Leukaemia; Myeloid; Chronic; Stem cells; Drug resistance; Protein kinase inhibitors
Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design
Keywords: مهار کننده های پروتئین کیناز; Protein kinase CK2; Casein kinase 2; CK2α/CK2β interaction; Conformational plasticity at the interdomain hinge region and the glycin-rich loop; Protein kinase inhibitors; CK2β antagonists binding at a remote docking site of CK2α;
(d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Iα
Keywords: مهار کننده های پروتئین کیناز; cGMP; cyclic guanosine 3â²,5â²-mono-phosphate; i.p.; intraperitoneal; i.v.; intravenous; Ki; inhibition constant; MAP; mean arterial blood pressure; Km; Michaelis-Menten constant; MPP; membrane-permeable peptides; PKA; cAMP-dependent protein kinase; P
Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
Keywords: مهار کننده های پروتئین کیناز; VEGF-R; EGF-R; Protein kinase inhibitors; N7/N9-Substituted 6-aminopurines
Interactions of methoxyacetic acid with androgen receptor
Keywords: مهار کننده های پروتئین کیناز; Ethylene glycol monomethyl ether; Methoxyacetic acid; Endocrine disruptive compounds; Androgen receptor; Testicular toxicity; Protein kinase inhibitors
Rapid fluorescent assay for screening drugs on Leishmania amastigotes
Keywords: مهار کننده های پروتئین کیناز; AlamarBlue; Leishmania donovani; Leishmania tropica; Amphotericin B; Staurosporine; Protein kinase inhibitors
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Keywords: مهار کننده های پروتئین کیناز; Met; Receptor tyrosine kinase; Protein kinase inhibitors
Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa
Keywords: مهار کننده های پروتئین کیناز; Protein G inhibitors; Protein kinase inhibitors; 2-Chloro-N6-cyclopentyladenosine; [Ca2+]i oscillations;
Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo
Keywords: مهار کننده های پروتئین کیناز; Human cytomegalovirus; Protein kinase inhibitors; Antiviral activity; Mode of action; Animal models; Drug development
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics
Keywords: مهار کننده های پروتئین کیناز; 2,4-Dianilino pyrimidines; Lck inhibitors; p56Lck inhibitors; Protein kinase inhibitors
Epidermal Growth Factor Receptor Mutations and Their Correlation with Gefitinib Therapy in Patients with Non-small Cell Lung Cancer: A Meta-Analysis Based on Updated Individual Patient Data from Six Medical Centers in Mainland China
Keywords: مهار کننده های پروتئین کیناز; Protein kinase inhibitors; Receptor; Epidermal growth factor; Carcinoma; Non-small cell lung; Meta-analysis; Chinese
Synthesis of analogs of the phenylamino-pyrimidine type protein kinase C inhibitor CGP 60474 utilizing a Negishi cross-coupling strategy
Keywords: مهار کننده های پروتئین کیناز; Negishi cross-coupling; Protein kinase inhibitors; Nucleophilic displacement; Phenylamino-pyrimidines;
LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance
Keywords: مهار کننده های پروتئین کیناز; Mouse leukaemia cells L1210; Multidrug resistance; P-glycoprotein; Vincristine; Akt kinase; Protein kinase inhibitors; LY 294,002; Protein phosphorylation
Kinetic studies of small molecule interactions with protein kinases using biosensor technology
Keywords: مهار کننده های پروتئین کیناز; Surface plasmon resonance; Protein kinase inhibitors; Drug discovery; Methodology; Binding rate constants; Biosensor;
Elevated expression of NF-κB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580
Keywords: مهار کننده های پروتئین کیناز; Myogenesis; NF-κB; Bcl-2; Protein kinase inhibitors; Apoptosis;