کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5272630 | 1385468 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effective synthesis of 3,5-diaryl-(1H)-pyrazin-2-ones via microwave mediated ring closure
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effective synthesis of 3,5-diaryl-(1H)-pyrazin-2-ones via microwave mediated ring closure Effective synthesis of 3,5-diaryl-(1H)-pyrazin-2-ones via microwave mediated ring closure](/preview/png/5272630.png)
چکیده انگلیسی
In this study we report on a flexible straight forward synthesis toward novel 3,5-diaryl-(1H)-pyrazin-2-ones. Our synthetic strategy involved an acyclic di-keto derivative as key intermediate. The final pyrazin-2-one ring closure reaction was yield-optimized by using a microwave mediated procedure and ammoniumacetate as nitrogen source. Our method is a suitable alternative to palladium-catalyzed coupling reactions for the 3,5-diaryl decoration of the (1H)-pyrazin-2-one scaffold. Since the (1H)-pyrazin-2-ones is present as scaffold in a number of biologically active compounds the reported synthetic platform is a useful approach to generate a set of highly diverse 3,5-diaryl-(1H)-pyrazin-2-one compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 31, 31 July 2013, Pages 4067-4072
Journal: Tetrahedron Letters - Volume 54, Issue 31, 31 July 2013, Pages 4067-4072
نویسندگان
Eugen Johannes, Rebecca Horbert, Joachim Schlosser, Dorian Schmidt, Christian Peifer,