کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5221503 1383422 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of O-H insertion for the attachment of phosphonates to nucleosides; synthesis of α-carboxy phosphononucleosides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Development of O-H insertion for the attachment of phosphonates to nucleosides; synthesis of α-carboxy phosphononucleosides
چکیده انگلیسی

Development of rhodium catalysed O-H insertion reactions employing α-diazophosphonates with appropriately protected adenosine, uridine and thymidine derivatives is described. This synthetic methodology leads, following deprotection, to novel phosphononucleoside derivatives bearing a carboxylic acid moiety adjacent to the phosphonate. Protection strategies are critical to the success of the key O-H insertion. There are two important aspects: avoiding competing insertion pathways or catalyst poisoning, and being able to achieve deprotection without degradation of the phosphononucleosides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 7, 18 February 2012, Pages 1894-1909
نویسندگان
, , , , , , ,