کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5222415 | 1383453 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells](/preview/png/5222415.png)
A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (Kd=4.3Â nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2Â ppb) of mercury ions in drinking water demanded by EPA. In addition, 3Â penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex.
Journal: Tetrahedron - Volume 67, Issue 22, 3 June 2011, Pages 4130-4136