کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5223185 1383479 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices
چکیده انگلیسی

The development and advantages of in situ synthesis of organic polymer monolith supports for metal pre-catalysts in narrow bore fused silica capillary microreactors are described. Catalyst immobilisation involves the covalent attachment of ligand binding sites to the porous polymer monolith, followed by coordination to metal centres. Flow-through microreactors using poly(chloromethylstyrene-co-divinylbenzene) monolith in capillaries of internal diameter 250 μm were used successfully for Suzuki-Miyaura and Sonogashira reactions, utilising both 1,10-phenanthroline and imidazole/carbene binding to palladium and with very low palladium leaching, illustrating the potential of flow-through technology at the microscale level using organic monolith support for transition metal catalysed reactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 7, 14 February 2009, Pages 1450-1454
نویسندگان
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