کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5224268 | 1383512 | 2009 | 6 صفحه PDF | دانلود رایگان |
Seven new polysulfur alkaloids, lissoclibadins 8 (1)-14 (7), were isolated from an ascidian, Lissoclinum cf. badium, collected in Indonesia. The structures were assigned on the basis of their spectroscopic data and computational modeling study. Lissoclibadin 8 (1) had four identical dopamine-derived units, and this is the first instance of a tetramer. Lissoclibadin 9 (2) was the second example of trimers next to lissoclibadin 1 (8). Lissoclibadins 10 (3)-12 (5) were symmetric dimers, and 13 (6) had a dopamine and ethyl units connected by sulfide and disulfide bonds. Lissoclibadin 14 (7) was a varacin-type monomer. These compounds inhibited the colony formation of Chinese hamster V79 cells and cell proliferation of murine leukemia L1210 cells.
Journal: Tetrahedron - Volume 65, Issue 46, 14 November 2009, Pages 9598-9603