کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224448 | 1383517 | 2009 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: 6,6â²-Dimethyl-2,2â²-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands 6,6â²-Dimethyl-2,2â²-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands](/preview/png/5224448.png)
We describe an efficient and scalable synthesis of 4-carbomethoxy-6,6â²-dimethyl-2,2â²-bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2,2â²-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a-c, 3a-g). The utility of this compound in the construction of more complex architectures was further demonstrated by the synthesis of two bifunctional lanthanide chelators; an open chain ligand based on one 2,2â²-bipyridine unit and a cryptand based on three 2,2â²-bipyridine units [N2(bpy)3COOMe]. In the field of luminophoric biolabels, the photophysical properties of the corresponding Eu(III) cryptate are reported.
Journal: Tetrahedron - Volume 65, Issue 36, 5 September 2009, Pages 7673-7686