کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224741 | 1383526 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support](/preview/png/5224741.png)
چکیده انگلیسی
Herein, we report the solid-phase synthesis of several 5-aminoimidazole-4-(N-alkyl)carboxamide-1-ribosides (4-N-alkyl AICARs) and the corresponding 2â²,3â²-secoriboside derivatives. The method uses the N-1-dinitrophenyl-inosine 5â²-bonded to a solid support. This inosine derivative has the C-2 of the purine base strongly activated towards the attack of N-nucleophiles thus allowing the preparation of several N-1 alkylated inosine supports from which a small library of 4-N-alkyl AICAR derivatives has been synthesized. A set of new 4-N-alkyl AICA-2â²,3â²-secoriboside derivatives have also been obtained in high yields by solid-phase cleavage of the 2â²,3â²-ribose bond.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 27, 30 June 2008, Pages 6475-6481
Journal: Tetrahedron - Volume 64, Issue 27, 30 June 2008, Pages 6475-6481
نویسندگان
Giorgia Oliviero, Jussara Amato, Nicola Borbone, Stefano D'Errico, Gennaro Piccialli, Enrico Bucci, Vincenzo Piccialli, Luciano Mayol,