کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5225095 1383537 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies on palladium-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines with organic halides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Studies on palladium-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines with organic halides
چکیده انگلیسی

A convenient route to optically active pyrazolidine derivatives from Pd(0)/(R,R)-Bn-BOX-catalyzed enantioselective cyclization of 3,4-allenylic hydrazines in the presence of organic halides has been developed, the ee value is 75-84%. The absolute configuration of the products was determined by the conversion of one of the products to a known product prepared in this group. The reaction may proceed via the oxidative addition, intermolecular carbometallation of the allene moiety forming a π-allylic palladium intermediate, and the intramolecular enantioselective allylation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 49, 1 December 2008, Pages 11159-11166
نویسندگان
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