کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5226134 | 1383567 | 2006 | 6 صفحه PDF | دانلود رایگان |
Four azaphilones named cohaerins C-F, along with 4,5,4â²,5â²-tetrahydroxy-1,1â²-binaphthyl were isolated from the methanolic extract of the stromata of Annulohypoxylon cohaerens (Ascomycetes, Xylariaceae). Cohaerins C-E constitute typical azaphilones, bearing a γ-lactone ring, while cohaerin F has an unprecedented carbon skeleton, lacking the lactone ring of the azaphilones and with an aliphatic side chain being attached directly to the azaphilone backbone by a C-C bond. Their structures were determined by 2D NMR, IR, UV, and CD spectroscopy. They showed moderate inhibitory activity of nitric oxide production in RAW cells, and strong and nonselective antimicrobial effects.
Four new antibiotic azaphilones named cohaerins C-F along with binapthyl were isolated and characterized from the xylariaceous fungus Annulohypoxylon cohaerens.
Journal: Tetrahedron - Volume 62, Issue 26, 26 June 2006, Pages 6349-6354