کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5226584 | 1383580 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of new steroidal derivatives by the reaction of steroid-amino acid conjugates with N,Nâ²-dicyclohexyl-carbodiimide. Unusual formation of steroidal imide derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of new steroidal derivatives by the reaction of steroid-amino acid conjugates with N,Nâ²-dicyclohexyl-carbodiimide. Unusual formation of steroidal imide derivatives Synthesis of new steroidal derivatives by the reaction of steroid-amino acid conjugates with N,Nâ²-dicyclohexyl-carbodiimide. Unusual formation of steroidal imide derivatives](/preview/png/5226584.png)
چکیده انگلیسی
Several new steroid derivatives have been synthesised by the reaction of steroid-amino acid conjugates with N,Nâ²-dicyclohexyl-carbodiimide. Selectivity of the reaction was found to depend greatly on the properties of the amino acid moiety. While the reaction of the glycine derivative led to the corresponding 5(4H)-oxazolone, an unusual imide formation together with an N-acylurea side product was observed in the case of conjugates of l-alanine, l-phenylalanine and l-methionine. The structures of the new products, steroidal imide and N-acylurea derivatives, were determined by various spectroscopic methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 24, 13 June 2009, Pages 4659-4663
Journal: Tetrahedron - Volume 65, Issue 24, 13 June 2009, Pages 4659-4663
نویسندگان
Eszter Takács, Zoltán Berente, Viktor Háda, Sándor Mahó, László Kollár, Rita Skoda-Földes,