کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5227255 1383600 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata
چکیده انگلیسی

Five novel prenylated polyketides, harrisotones A-E (1-5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A-E (1-5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR and CD spectra. A plausible origin of compounds 1-5 was rationalized biogenetically, and traced back to harrisonol A (6). Harrisotones A-C (1-3) and harrisonol A (6) exhibited significant cytotoxicity against P-388 and/or A-549 tumor cell lines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 6, 7 February 2009, Pages 1147-1152
نویسندگان
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