Synthesis and structural characterisation of novel platinum-based drug candidates with extended functionality by incorporation of bis(diphenylphosphino)ferrocene units as metal chelators

We here report a synthetic pathway for the construction of several unique dppf-based platinum compounds with chemical modifications introduced in the ferrocenyl moiety. A nucleoside-based cis-platinum compound showed both improved water solubility and promising kinetics with DNA models with a reactivity similar to cisplatin.