کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5227836 | 1383617 | 2007 | 10 صفحه PDF | دانلود رایگان |
Presented is a description of the design, synthesis, and characterization of a novel, branched, six hydrogen-bonded heterodimer termed 'trident'. Two branched oligoamide molecules, 1 and 2, with complementary hydrogen-bonding sequences 3(AD) and 3(DA), respectively, were found to form a very stable (Kaâ¥9Ã106 Mâ1) heterodimer in chloroform. Confirmation of the high stability of the heterodimer was obtained through 1D and 2D 1H NMR spectroscopy, thin-layer chromatography (TLC), and vapor pressure osmometry (VPO). The stability of the trident occurs through the cooperative action of six programmed hydrogen-bonding interactions, which are facilitated by the pre-organization of the individual strands through intramolecular hydrogen bonding.
A 1:1 ratio of synthesized oligoamides 1 and 2 tightly bind in chloroform to form a very stable six hydrogen-bonded heterodimer 1·2.
Journal: Tetrahedron - Volume 63, Issue 25, 18 June 2007, Pages 5460-5469