کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5228127 | 1383625 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Asymmetric total synthesis of B-ring modified (â)-epicatechin gallate analogues and their modulation of β-lactam resistance in Staphylococcus aureus
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Asymmetric total synthesis of B-ring modified (â)-epicatechin gallate analogues and their modulation of β-lactam resistance in Staphylococcus aureus Asymmetric total synthesis of B-ring modified (â)-epicatechin gallate analogues and their modulation of β-lactam resistance in Staphylococcus aureus](/preview/png/5228127.png)
چکیده انگلیسی
Two enantiomerically pure B-ring modified analogues of (â)-epicatechin gallate were synthesised and their modulation of β-lactam resistance using three strains of methicillin resistant Staphylococcus aureus (BB 568, EMRSA-15 and EMRSA-16) evaluated. Sub-inhibitory concentrations (12.5 and 25 mg/L) of the two analogues fully sensitised each of the three MRSA strains to oxacillin, reducing the MIC to less than 0.5 mg/L, identical to levels achieved with ECg. Lower concentrations demonstrated that the position and degree of hydroxylation of the B-ring is important for activity.
Graphical Abstract
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 61, Issue 32, 8 August 2005, Pages 7703-7711
Journal: Tetrahedron - Volume 61, Issue 32, 8 August 2005, Pages 7703-7711
نویسندگان
James C. Anderson, Catherine Headley, Paul D. Stapleton, Peter W. Taylor,