کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5228547 1383636 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parallel kinetic resolution of propargyl ketols: formal synthesis of (+)-bakkenolide A
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Parallel kinetic resolution of propargyl ketols: formal synthesis of (+)-bakkenolide A
چکیده انگلیسی

We describe an intriguing new example of a parallel kinetic resolution; an asymmetric cyclization-carbonylation of propargyl ketols catalyzed by palladium(II) with chiral bisoxazoline (box) ligands. The 2S,3S enantiomer of (±)-6 was preferentially converted to 13 (45-49% yields, 37-46% ee), and the 2R,3R enantiomer of (±)-6 was preferentially converted to 14 (21-23% yields, 92-97% ee). As an application of this reaction, formal synthesis of (+)-bakkenolide A was achieved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 20, 12 May 2008, Pages 4627-4636
نویسندگان
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