CuI/L (L=pyridine-functionalized 1,3-diketones) catalyzed C-N coupling reactions of aryl halides with NH-containing heterocycles

An efficient copper-catalyzed N-arylation and N-heteroarylation reactions of imidazole, pyrrole, indole, pyrazole, and perimidine with aryl or heteroaryl halides using pyridine-functionalized 1,3-diketone as ligands have been investigated. The ligands bearing pyridyl and 1,3-diketone moieties, which may form chelated Cu(I) species, are inexpensive and readily available. The combination of CuI and 1,3-di(pyridine-2-yl)propane-1,3-dione is very efficient for C-N coupling reactions to afford various N-arylated products in good to excellent yields.