Synthesis of some multi-β-substituted cationic porphyrins and studies on their interaction with DNA

A series of multi-β-substituted cationic porphyrins have been synthesized. Their photooxidative abilities and interactions with DNA were investigated. Substituents at β-position of the porphyrins have significant effect on the interactions and binding modes of the porphyrins with DNA compared to the β-unsubstituted one. Increasing positive charges in porphyrins strengthen their interactions with DNA.