Synthesis of α-acylamino-amide-bis (indolyl) methane heterocycles by sequential one pot condensation-Ugi/Passerini reactions and their antimicrobial evaluation

New bis (indolyl) methane based heterocycles were developed by a proficient sequential synthesis in one pot where substituted aromatic aldehydes, isocyanides were varied, producing a library of benzamide and benzoate analogues with multiple points of diversity. The synthesized analogues were tested for their antimicrobial potency against gram positive and gram negative pathogenic bacteria.