کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5262501 | 1385183 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lewis acid mediated highly regioselective intramolecular cyclization for the synthesis of β-lapachone
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A highly regioselective intramolecular cyclization of lapachol mediated by Lewis acids including NbCl5, AlCl3, and FeCl3 was developed for synthesizing β-lapachone in excellent yields without any formation of the isomer α-lapachone. This procedure was efficient, mild, and easily scalable that avoided using highly hazardous concd H2SO4. In the case of ZrCl4 the cyclization was found to give α-lapachone as the main product. A possible mechanism for the Lewis acid mediated cyclization was also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 8, 19 February 2014, Pages 1475-1478
Journal: Tetrahedron Letters - Volume 55, Issue 8, 19 February 2014, Pages 1475-1478
نویسندگان
Jinlei Bian, Bang Deng, Xiaojin Zhang, Tianhan Hu, Nan Wang, Wei Wang, Haixiang Pei, Yu Xu, Hongxi Chu, Xiang Li, Haopeng Sun, Qidong You,