Cu(I) metal organic framework catalyzed C-C and C-N coupling reactions

DABCO (1,4-diazabicyclo[2.2.2]octane) based Cu(I) metal organic framework (here after represented as Cu(I)-MOF) catalyzed Sonogashira cross-coupling reaction of iodobenzene and phenylacetylene was conducted smoothly to afford diphenylacetylene in excellent yield under N2 atmosphere. For comparative study, piperidine based Cu(I) clusters were also investigated. Among these catalysts, Cu(I)-MOF exhibited higher activity with good selectivity for the C-C cross-coupled product. Cu(I) catalysts investigated in this study exhibited similar activity in the C-C homo-coupling reaction of phenylacetylene in O2 atmosphere. Application of these catalysts was extended in the C-N coupling reactions between phenylboronic acid and aromatic/aliphatic/heterocyclic amines. Cu(I)-MOF can be readily recovered from the reaction mixture and reused for several cycles without loss in the catalytic activity.