Enantioselective fluorination of α-chloro-β-keto phosphonates in the presence of chiral palladium complexes

The catalytic enantioselective electrophilic fluorination of α-chloro-β-keto phosphonates promoted by chiral palladium complexes has been developed, allowing facile synthesis of the corresponding α-chloro-α-fluoro-β-keto phosphonates with excellent enantioselectivity (up to 95% ee).