Synthesis of 6-aryluridines via Suzuki-Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water

A new and efficient ligandless cross-coupling reaction of 6-iodouridine with various boronic acids in the presence of Na2PdCl4 was performed at room temperature in aerobic water. The target 6-aryl analogues were obtained in moderate to good yields depending on the boronic acid nature.