کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5264910 | 1385270 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts](/preview/png/5264910.png)
چکیده انگلیسی
A new operationally simple and robust protocol for the metal-free atom transfer radical reaction (ATRA) has been developed. Polychlorinated compounds were effectively reacted with unactivated terminal olefins to generate 1,3-dichlorinated adducts under microwave irradiation in the presence of silicon carbide (SiC) as a heating element. The present microwave-assisted ATRA proceeds under essentially neutral conditions; thus, polar functionalities are well tolerated. In addition, an oxygen or a nitrogen unit was introduced to the internal side of the carbon chain via nucleophilic cyclization of the 1,3-dichlorinated adducts, and single-step formation of the six-membered carbocycle was realized through cyclization of the intermediate radical. The present methodology provides an expeditious way to prepare synthetically useful molecules from simple and unactivated terminal olefins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 33, 15 August 2012, Pages 4368-4371
Journal: Tetrahedron Letters - Volume 53, Issue 33, 15 August 2012, Pages 4368-4371
نویسندگان
Shin Kamijo, Shoko Matsumura, Masayuki Inoue,