Ligand-free copper nanoparticle promoted N-arylation of azoles with aryl and heteroaryl iodides

A relatively mild, efficient, and inexpensive method for the nucleophilic aromatic substitution of the N-H heterocycles with various aryl and heteroaryl iodides using copper nanoparticles (Cu-NP) is reported. The coupling reaction has been successfully achieved with moderate to good yields.