کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5266610 | 1385315 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Highly asymmetric Henry reaction catalyzed by chiral copper(II) complexes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two chiral pyridinylmethyl diphenylprolinolsilyl ether derivatives have been synthesized from N-alkylation of (S)-diphenylprolinolsilyl ether in a single step. They were successfully applied as ligands in the Cu(II)-catalyzed enantioselective Henry reaction between aldehydes and nitromethane in ethanol at room temperature. A variety of chiral Henry products β-nitroalcohols were obtained in good to high yields (up to 94%) with high to excellent enantioselectivities (up to 94% ee) under the optimized reaction conditions. The results indicate that the bulky substituent diphenylprolinolsilyl ether of ligand 2 plays an important role to induce the high stereoselectivity of the process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 6, 6 February 2013, Pages 462-465
Journal: Tetrahedron Letters - Volume 54, Issue 6, 6 February 2013, Pages 462-465
نویسندگان
Bukuo Ni, Junpeng He,