کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5267758 1385345 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of functionalized tetrahydroisoquinolines via palladium-catalyzed 6-exo-dig carbocyclization of 2-bromo-N-propargylbenzylamines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of functionalized tetrahydroisoquinolines via palladium-catalyzed 6-exo-dig carbocyclization of 2-bromo-N-propargylbenzylamines
چکیده انگلیسی

An efficient twostep synthetic strategy for tetrahydroisoquinolines has been described. The first step involves CuI catalyzed three-component coupling reaction of terminal alkyne, aldehyde and amine that provides the requisite propargyl amine. Regio- and stereoselective palladium-catalyzed 6-exo-dig carbocyclization of propargyl amine, which provides a concise access to functionalized tetrahydroisoquinolines in good yields has been developed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 14, 6 April 2011, Pages 1644-1648
نویسندگان
, , ,