DNA-, RNA- and self-pairing properties of a pyrrolidinyl peptide nucleic acid with a (2′R,4′S)-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone

A pyrrolidinyl peptide nucleic acid (PNA) with an alternating nucleobase-modified proline at the 4′ position with (2′R,4′S) configuration and a (1S,2S)-2-aminocyclopentane-carboxylic acid backbone was synthesized and its DNA-, RNA- and self-pairing properties evaluated.